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UCT Prague
Technická 5
166 28 Prague 6 – Dejvice
Identification No.: 60461373
VAT: CZ60461373
Copyright: UCT Prague
Information provided by the Department of Communication.
Sitemap
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- Title: Talking microbes - understanding microbial interactions within One Health framework
- Acronym: INTER-MICRO
- Coordinator: Jan Jansa
- Participating institutions:
- Duration: 1 January 2024 – 30 June 2028 (54 months)
- Total cost: 436.5 million CZK
- Project reference: CZ.02.01.01/00/22_008/0004597
- Funded under: Ministry of Education, Youth and Health of the Czech Republic, Programme Johannes Amos Comenius OP JAK, co-financed by the European Union EU
Project goals
- To identify novel signalling molecules (i.e., the “words” in chemical cross-talk) involved in communication between prokaryotic microbes and/or microbes and their eukaryotic hosts.
- To elucidate the mode of action of the previously established and novel signalling molecules, thus assembling the “sentences” and “messages”.
- To successfully manipulate the eukaryotic-associative microbiome by changing the nutrient/energy inputs (diet), composition of starting microbiomes and by using the signalling molecules or their silencers, i.e. the “microbial language”.
- To describe links between diet, associative microbiome and on-set and development of nutritional and health disorders in model eukaryotic hosts (e.g., fish, mouse, pig, soybean, mycorrhizal fungus).
- To identify prokaryotic microbes, metabolic pathways and their regulation involved in the degradation of complex biomolecules or toxins of biological or industrial origin.
- To describe ecosystem-wide microbiome shifts and their functional consequences in response to land use and global changes such as nutrient enrichment, drought, and biological invasions.
The list of publications will appear here as soon as some are published.
(The project was started on 1. 1. 2024.)
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- Jan Jansa
jansa@biomed.cas.cz
(+420) 296 442 652
Chief Project Manager
- Tomáš Pěnek
Contact for Media
- Nikola Vildová
nikola.vildova@biomed.cas.cz
+420 241 062 383
Institute of Microbiology of the CAS, v. v. i.
Vídeňská 1083
Prague 4 – Krč
142 20
Czech Republic
ID: 61388971
VAT ID: CZ61388971
Datoa box: ndpn2cp
Webmaster
- Jitka Čejková
cejkovaj@vscht.cz
(+420) 220 444 460
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[obsah] => Words and sentences in microobial communication
Main focus of the WP1 is on chemical signals (i.e., the “words” and “sentences” in microbial communication) and mechanisms of communication between microbes within populations (single species) and communities (multiple species), and microbes and their eukaryotic hosts. This will include identification of novel signalling compounds as well as uncovering molecular mechanisms of their transfer, sensing, and regulation at fine spatial and temporal scales. Advanced metabolomics, microscopy, biochemistry and molecular genetics approaches are to be combined to gather new knowledge and also to supply the other WPs with putative signalling compounds for testing in more complex biological systems.
Leader:
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Team:
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- Silvia Bezoušková
- Pavla Bojarová
- Oliva Branná
- Pavel Branny
- Ludmila Brázdilová
- Ladislav Bumba
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- Monika Čížková
- Linda Doubravová
- Michaela Grobarčíková
- Michal Grulich
- Vladimír Havlíček
- Jana Holubová
- Jiří Houšť
- Jiří Janata
- Stanislav Kadlčík
- Jana Kamanová
- Milada Kambová
- Zdeněk Kameník
- Markéta Koběrská
- Viola Kolaříková
- Vladimír Křen
- Anna Lepesheva
- Dominika Luptáková
- Helena Marešová
- Jiří Mašín
- Aninda Mazumdar
- Mufarrah Mehboob
- Hana Michova
- Lucie Najmanová
- Pavlína Nekvasilová
- Jiří Novák
- Michaela Novotná
- Andrea Palyzová
- Barbora Petránková
- Lucie Petrásková
- Kristýna Slámová
- Ondřej Staněk
- Tomasso Stefani
- Peter Šebo
- Aleš Ulrych
- Waheed Ur Rahman
- Kateřina Valentová
- Pavel Vávra
- Tomáš Vomastek
- WP 1 Words and sentences in microobial communication
- WP 2 Talking to microbes – innovative signal delivery systems
- WP 3 Microbial conversation for the host health
- WP 4 Microbial conversation for the health of ecosystems
Talking to microbes – innovative signal delivery systems
The focus of WP2 is on development of chemical micro-robots capable of emitting or scavenging specific molecular signals within biological systems, in order to induce reproducible changes in their microbiome composition and activity, and/or host responses. Additionally, possibilities will be sought to encapsulate living microbes for their targeted delivery in pre-defined spatial and temporal patterns. The overall goal is to improve our understanding of microbial “language” and use this knowledge for practical applications in research, biomedicine, agriculture, and/or food processing.
Leader
- František Štěpánek
Team
- Adéla Brejchová
- Jitka Čejková
- Suada Dukaj
- Eva Králová
- Martin Krov
- Anna Ludvíková
- Lucie Mašková
- Elizaveta Mutylo
- Ondřej Navrátil
- Tomáš Nejedlý
- Ivan Saloň
- František Štěpánek
- Viola Tokárová
- Jan Trnka
- Jitka Viktorová
- Aleš Zadražil
- Filip Zavřel
- Miluše Zimolová
- WP 1 Words and sentences in microobial communication
- WP 2 Talking to microbes – innovative signal delivery systems
- WP 3 Microbial conversation for the host health
- WP 4 Microbial conversation for the health of ecosystems
Microbial conversation for the host health
The aim of the WP3 is to uncover consequences of host-microbiome interactions induced by diet/environmental conditions for nutrition and health of eukaryotic host such as mouse, pig, or a fungus. Besides local processes, the effects will be studied of animal gut microbiome composition on epithelial barrier function and distal organs such as brain, and on the development and functioning of the mammalian immune system. Using gnotobiotic experimental models allows for precise control over the microbiome composition/activity, provides unique opportunity to establish causal links between putative signalling compounds identified in WP1, delivered via vehicles developed in WP2, and the broad eco-evolutionary context (further elaborated in WP4).
Leader
- Martin Schwarzer
Team
- Dagmar Čížková
- Markéta Harazim
- Kateřina Marková
- Jan Náhlovský
- František Vostárek
- Lyubina Adámková
- Evgeniya Biryukova
- Štěpán Coufal
- Adéla Čmoková
- Anna Maria Frontino
- Roman Hájek
- Petr Halada
- Tomáš Hudcovic
- Anna Jelínková
- Janet Ježková
- Zuzana Jirásková-Zakostelská
- Michael Karpíšek
- Klára Kostovčíková
- Michal Kraus
- Jakub Kreisinger
- Zdeněk Kukačka
- Umesh Kumar Gautam
- Miloslav Kverka
- Šárka Maisnerová
- Petr Man
- Halil Mert Solak
- Tereza Novotná
- Šárka Pfeiferová
- Petra Procházková
- Radka Roubalová
- Martin Schwarzer
- Marek Šinkora
- Dagmar Šrůtková
- Tomáš Thon
- Jaroslava Valterová
- Daniel Vaz de Oliveira
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- WP 1 Words and sentences in microobial communication
- WP 2 Talking to microbes – innovative signal delivery systems
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- WP 4 Microbial conversation for the health of ecosystems
Microbial conversation for the health of ecosystems
Aims of the WP4 are to understand the drivers shaping plant rhizosphere and endosphere microbiomes, the consequences of human activities at both local and global scales for the plant and soil microbiomes, and how this affects health, resistance and resilience of plant communities and the entire ecosystems. Further, efforts are to be invested into understanding which microbes participate in recycling of complex organic (macro)molecules and toxins being produced by plants or other microbes, or those originating from human activities. The ultimate goal is to improve our understanding of ecosystem functioning and to use such knowledge to refine predictions on the possible outcomes of global changes for plant and microbial invasions and ecosystem stability, and to propose new ways to remediate polluted environments.
Leader
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Team
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- Valeriia Belova
- Petra Bukovská
- Stephanie Campeggi
- Anna Davidová
- Tomáš Engl
- Jan Jansa
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- Jakub Papík
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- Jakub Skřivánek
- Michal Strejček
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- Tereza Šmrhová
- Jáchym Šuman
- Manuela Tadrosová
- Ondřej Uhlík
- Tomáš Větrovský
- Andrea Zubrov
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- WP 2 Talking to microbes – innovative signal delivery systems
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- WP 4 Microbial conversation for the health of ecosystems
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Leader: Jana Kamanová
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Leader: František Štěpánek
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