- Tomáš Pěnek
- Lucie Najmanová
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- Title: Talking microbes - understanding microbial interactions within One Health framework
- Acronym: INTER-MICRO
- Coordinator: Jan Jansa
- Participating institutions:
- Duration: 1 January 2024 – 30 June 2028 (54 months)
- Total cost: 436.5 million CZK
- Project reference: CZ.02.01.01/00/22_008/0004597
- Funded under: Ministry of Education, Youth and Health of the Czech Republic, Programme Johannes Amos Comenius OP JAK, co-financed by the European Union EU
Project goals
- To identify novel signalling molecules (i.e., the “words” in chemical cross-talk) involved in communication between prokaryotic microbes and/or microbes and their eukaryotic hosts.
- To elucidate the mode of action of the previously established and novel signalling molecules, thus assembling the “sentences” and “messages”.
- To successfully manipulate the eukaryotic-associative microbiome by changing the nutrient/energy inputs (diet), composition of starting microbiomes and by using the signalling molecules or their silencers, i.e. the “microbial language”.
- To describe links between diet, associative microbiome and on-set and development of nutritional and health disorders in model eukaryotic hosts (e.g., fish, mouse, pig, soybean, mycorrhizal fungus).
- To identify prokaryotic microbes, metabolic pathways and their regulation involved in the degradation of complex biomolecules or toxins of biological or industrial origin.
- To describe ecosystem-wide microbiome shifts and their functional consequences in response to land use and global changes such as nutrient enrichment, drought, and biological invasions.
The list of publications will appear here as soon as some are published.
(The project was started on 1. 1. 2024.)
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- Jan Jansa
jansa@biomed.cas.cz
(+420) 296 442 652
Chief Project Manager
- Tomáš Pěnek
Contact for Media
- Nikola Vildová
nikola.vildova@biomed.cas.cz
+420 241 062 383
Institute of Microbiology of the CAS, v. v. i.
Vídeňská 1083
Prague 4 – Krč
142 20
Czech Republic
ID: 61388971
VAT ID: CZ61388971
Datoa box: ndpn2cp
Webmaster
- Jitka Čejková
cejkovaj@vscht.cz
(+420) 220 444 460
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[text] => This project is implemented in a consortium of three top research institutions under the leadership of the Institute of Microbiology of the Czech Academy of Sciences (IMIC). The partners are the University of Chemistry and Technology, Prague (UCT) and Charles University (CUNI).
Approximately one third of the research groups currently established within IMIC will participate in the proposed project (WP1, WP3 and WP4). They cover by their expertise the fields of molecular biology and enzymology, organic and analytical chemistry, microbiology, immunology and microbial ecology, the study of complex ecosystems including bioinformatics, cell signalling, structural biology and germ free (GF) animal models (unique in the Czech Republic). The selection of the scientific groups therefore technologically and professionally covers the entire spectrum of the complex tasks to be solved, with the exception of WP2 activities, which are fully secured by the team of Prof. Štěpánek, the ERC grant holder (UCT). This team has a unique technology, the use of which is crucial for most downstream project activities. On the other hand, critical recommendations for upgrading the technology of the UCT will be based on the research of the IMIC and CUNI teams. The participating research teams from the CUNI have been selected on the basis of long-term cooperation with IMIC teams of WP3 and complement the necessary know-how to ensure that all planned project activities are fully supported both in terms of personnel and technology. IMIC continuously follows and evaluates current trends and needs in the field of research, development and innovation and also focuses on contract research and production in the fields of biology, chemistry and medical sciences. The UCT has even more extensive experience in the field of applied research. This long-term experience guarantees the recognition and effective usage of the project activities application potential.
International Scientific Advisory Board
The International Scientific Advisory Board (ISAB) of the project is composed of six members who were nominated so that their expertise covers the whole spectrum of the proposed project activities. Date of the annual project meeting with ISAB members: 14-15 October 2024.
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